Speaker
Luciano Branco
Date
Location
S105
Abstract
Parkinson’s Disease (PD) is a complex neurodegenerative disorder characterized by diverse symptoms. Deep Brain Stimulation (DBS) targeting the subthalamic nucleus (STN) and globus pallidus internus (GPi) effectively manages motor symptoms, with neurophysiological biomarkers from Local Field Potentials (LFPs) offering insights to optimize therapy. Previously, our lab demonstrated the Beta band activity and high-frequency oscillations (HFOs) may help identify patient-specific neural signatures and differentiate PD subtypes. Additionally, Evoked Resonant Neural Activity (ERNA) is a recently discovered biomarker that reflects direct responses to stimulation. Interactions between ERNA and HFOs may guide DBS parameter selection such as stimulation amplitude, frequency and contact selection. Leveraging these biomarkers may enable real-time recalibration of dysfunctional circuits, enhancing DBS efficacy and tailoring therapy to individual patient needs.