Alexander Oraevsky

Adjunct Professor

Office Location 7505 Fannin Street, Ste 500, Houston, TX 77054-1943

Phone 713-282-9353

Email aaoraevs [at] cougarnet.uh.edu

Dr. Alexander A. Oraevsky has over 30 years of experience managing research and development laboratories in academia and small businesses. He is a pioneer in the field of biomedical optoacoustics. Alexander received his initial training in physics and mathematics from the Moscow Physical and Engineering Institute in Moscow, Russia and obtained a doctorate in laser spectroscopy and laser biophysics from the USSR Academy of Sciences in 1986. He began his pioneering research in the field of optoacoustic imaging, sensing, and monitoring in 1987. In 1992, as Whitaker Fellow, he joined the faculty at Rice University, Houston, Texas. He was the Director of the Optoacoustic imaging and Spectroscopy Laboratory at the University of Texas Medical Branch in Galveston, TX and an Assistant Professor at the Department of Ophthalmology and Visual Sciences. In 1998 Dr. Oraevsky founded LaserSonix Technologies, the first company dedicated to commercialization of optoacoustic imaging systems based on the core patent filed in 1996. Presently, Dr. Oraevsky is the holder of 22 US patents and their international families, has published 12 book chapters and over 250 scientific papers dealing with novel laser technologies applicable in biology and medicine. Before founding TomoWave Laboratories in 2010 (presently TomoWave, Inc), he was Vice President of R&D at Fairway Medical Technologies. Being business strategist for TomoWave, Alexander continues to lead the research community of biomedical optoacoustics he created by founding and Chairing international conference on “Photons plus Ultrasound: Imaging and Sensing” the largest forum in the area of biomedical optoacoustics held annually under auspices of International Society of Optics and Photonics Engineers (SPIE). Dr. Oraevsky also holds an adjunct Professor position at the Biomedical Engineering Department of the University of Houston. He is the recipient of over $19M in major research grants from NIH, DOD and other sponsors advancing the science of optoacoustics for clinical applications in the areas of early detection, diagnostics and minimally invasive therapy of cancer and vascular diseases.

Education

Ph.D., Laser Spectroscopy, Photochemistry and Biophysics, Institute of Spectroscopy, USSR Academy of Sciences, Russia

M.S., Ultrafast Laser Spectroscopy of Biomolecules, Moscow Physical and Engineering Institute, Russia

B.S., Theoretical and Experimental Physics Moscow Physical and Engineering Institute, Russia

Courses

1986-1989, Laser Photochemistry, graduate course, Institute of Spectroscopy, Russian Academy of Sciences.

1993, Tissue Engineering, Short Course for Continuing Studies, "Laser Biomedical Diagnostics and Treatment", Rice University.

1994 -1998, Two original courses for undergraduate and graduate students: "Fundamentals of Biomedical Photonics" and "Laser Biomedical Instrumentation", Biomedical Engineering Program, Electrical and Computer Engineering Department, Rice University.

1999, Supervision of a High School Teacher participated in Texas HECB Advanced Technology Supplemental Program.

2000-2002, Facilitator, Problem Based Learning at SOM, UTMB, “Great Syndromes” Course (2000), “Tissues-Cells-Molecules” Course.

2000-2004, Educational Program at SPIE Photonics West Symposium, course “Optoacoustic Tomography”.

2009, “Optoacoustic imaging and sensing”, Graduate study short course, the University of Houston.

Awards and Honors

2025 - Member of Forbes Technology Council

2022 - The Best Paper Award, SPIE Photonics West Symposium, Conference on “Photons Plus Ultrasound: Imaging and Sensing” (paper on Quantitative Optoacoustic Tomography).

2021 - Elected Fellow of Optica (Optical Society of America)

2017 - Santander Award and Chair of Excellence Grant for the project “Laser optoacoustic and Laser ultrasound endoscopy of cancer using high power diode lasers”, University of Carlos III, Madrid Spain

2016 - Elected Fellow of International Society of Photonics Engineering (SPIE)

2015 - James Smith Award from the International Photoacoustic and Photothermal Association for pioneering research, development and seminal contributions to biomedical photoacoustic (optoacoustic) imaging.

2014 - Berthold Leibinger Innovations Prize, the First Place Award for the invention and development of the “Laser Optoacoustic Imaging System and its biomedical applications”.

2009 - The Best Paper Award, SPIE Photonics West Symposium, Conference on “Photons Plus Ultrasound: Imaging and Sensing” (Paper on Laser Optoacoustic Imaging System, LOIS-3D).

1989 - “Outstanding Young Faculty Award”, Institute of Spectroscopy, USSR Academy of Sciences, Moscow, Russia.

1987 - Academy of Sciences Award for young researchers for the project "Optical monitoring of neuron activity", Moscow, Russia.

Professional Activities

SPIE / Society of Photo-Optical Instrumentation Engineers (Fellow

Optica / Optical Society of America (Fellow)

BIOS / Biomedical Optics Society (Fellow)

IEEE / Institute of Electrical and Electronic Engineers (Biomedical Engineering)

Research Interests

Optoacoustic Imaging (Tomography, Microscopy, Endoscopy, Sensing) of Tissue and Cell

Biomedical Optics and Imaging of Nanoparticles

Laser Fluorescence Microscopy and Spectroscopy

Laser Photochemistry of Biomolecules

Medical Diagnostics, Image guided surgery, Monitoring thermal therapy

Pulsed Laser Ablation of Tissues and Biomaterials

Photothermal, Photomechanical and Photochemical Tissue Effects

Laser Physics, Optical Systems

Funding Received

US Army /DOD Breast Cancer Imaging Program, “Spectroscopic optoacoustic tomography for diagnostic imaging of early breast cancer”, 4/1/2004- 3/31/2006

NIH/NCI, R43/R44 Subcontract, “Optoacoustic and Ultrasonic Imaging of Angiogenesis”, 4/01/2005 – 3/30/2007

NIH/NCI, R43/R44 (SBIR Phase I and Phase II) "Optoacoustic imaging enhanced with gold nanorods”, 10/1/2005-9/30/2009

NIH/NCI, R43/R44 (SBIR Phase I plus Phase II) “Optoacoustic image guided biopsy of prostate cancer”, 4/1/2006 – 3/30/2009

DoD/ Alliance for Nanohealth, Image guided Laser Activated Nano-Thermolysis of Leukemia Cells from bone marrow transplants”, 11/1/2006 – 10/30/2007

NIH/NCI, R43/R44 (SBIR Phase I plus Phase II) “3D Hybrid Optoacoustic-Ultrasonic System for Diagnostic Imaging of Breast Cancer”, 9/1/2007 – 8/30/2010

Office of Naval Research, (Subcontract from SA UTHSC) “Rapid Identification of pathogenic agents biological samples using pulsed laser optoacoustic spectroscopy with targeted nanoparticle contrast agent”, 2/1/2008 – 1/30/2011

NIH/NCI, American Recovery and Reinvestment Act Program, “Novel Nanotechnology based contrast agents for optoacoustic imaging”, 9/1/2009 – 8/30/2010

NIH/NCI, R01 "Multimode laser optoacoustic tomography system for breast cancer care", 4/1/2012-3/30/2017.

NIH/NIHD, R43 “Point-of-care monitoring of feto-placental oxygen uptake”, 4/1/2018-3/30/2019.

NIH/NIBIB, R01 “Computational Framework Enabling Virtual Imaging Trials of 3D Quantitative Optoacoustic Tomography Breast Imaging”, 4/1/2022-3/31/2026.

Selected Publications

R. Su, S. Park, U. Villa, M.A. Anastasio, A.A. Oraevsky, Functional Three-Dimensional Optoacoustic Tomography of Live Mouse Body and Brain, IEEE Med. Imaging 2025; 27: in review.
P. Chen, S. Park, R.M. Cam, H-K. Huang, A.A. Oraevsky, U. Villa, M.A. Anastasio: Learning a Filtered Backprojection Reconstruction Method for Photoacoustic Computed Tomography with Hemispherical Measurement Geometries, IEEE Trans. Med. Imaging, 2024: xx: xxx (DOI: 10.1109/TMI.2025.3591706).
M. Sanchez, D. Gallego, A.A. Oraevsky, H. Lamela: A laser ultrasound emitter based on high-power diode laser in overdrive operation mode for biomedical imaging applications, Ultrasonics 2025; 148, 107548 DOI: 10.1016/j.ultras.2024.107548
S. Park, U. Villa, Fu Li, R.M. Cam, A.A. Oraevsky, M.A. Anastasio: Stochastic three-dimensional numerical phantoms to enable computational studies in quantitative optoacoustic computed tomography of breast cancer, J. Biomedical Optics 2023; 28(6): 066002.
S. Park, F.J. Brooks, U. Villa, R. Su, M.A. Anastasio, A.A. Oraevsky, Normalization of optical fluence distribution for three-dimensional functional optoacoustic tomography of the breast, J. Biomed. Opt. 2022; 27(3): 210367GR. [DOI: 10.1117/1.JBO.27.3.036001]
J. Zalev; L.M. Richards; B.A. Clingman; J. Harris; E. Cantu; G.L.G. Menezes; C.A. Avila; A. Bertrand; X.R. Saenz; S.C. Miller; A.A. Oraevsky; M.C. Kolios: Optoacoustic imaging of relative blood oxygen saturation and total hemoglobin for breast cancer diagnosis. J. Biomedical Optics 2019; 24(12): 121915. doi.org/10.1117/1.JBO.24.12.121915
Y. Lou, S. Park, F. Anis, R. Su, A.A. Oraevsky, M.A. Anastasio, Analysis of the use of unmatched backward operators in iterative image reconstruction with application to three-dimensional optoacoustic tomography, IEEE Trans Computer Imaging, 2019; 5(3): 437-449. [DOI 10.1109/TCI.2019.2895217].
A.A. Oraevsky, B. Clingman, T. Stavros; J. Parikh, W.T. Yang: Clinical Optoacoustic Imaging Combined with Ultrasound for Coregistered Functional and Anatomical Mapping of Breast Tumors, Photoacoustics 2018; 8: 2345-2351. DOI.org/10.1016/j.pacs.2018.08.003.
E.V. Petrova, H.P. Brecht, M. Motamedi, A.A. Oraevsky, S.A. Ermilov: In vivo optoacoustic temperature imaging for image-guided cryotherapy of prostate cancer, Phys. Med. Biol. 2018; 63(6) 064002. doi:10.1088/1361-6560/aab241
D.L. Longo, R. Stefania, S. Aime, A.A. Oraevsky: Melanin-Based Contrast Agents for Biomedical Optoacoustic Imaging and Theranostic Applications. Int. J. Mol. Sci. 2017; 18: 1719-1739.
E. Petrova, A. Liopo, S.A. Ermilov, A.A. Oraevsky: Temperature-dependent optoacoustic response and transient through zero Grüneisen parameter in optically contrasted media. Photoacoustics 2017; 7: 36-46. doi: 10.1016/j.pacs.2017.06.002
Y. Lou, K. Wang, A.A. Oraevsky, M.A. Anastasio: Impact of non-stationary optical illumination on image reconstruction in optoacoustic tomography. JOSA-A 2016; 33(12): 2333-2347; doi: 10.1364/JOSAA.33.002333
A. Liopo, R. Su, D. Tsyboulski, A.A. Oraevsky: Optical clearing of skin enhanced with hyaluronic acid for increased contrast of optoacoustic imaging. J Biomed Opt, 2016; 21(8): 081208-8, doi: 10.1117/1.JBO.21.8.081208
S.M. Maswadi, B.L. Ibey, C.C. Roth, D. A. Tsyboulski, H.T. Beier, R.D. Glickman, A.A. Oraevsky: All-optical optoacoustic microscopy based on probe beam deflection technique. Photoacoustics 2016; 2(1): 98-109; doi:10.1016/j.pacs.2016.02.001
S.A. Ermilov, R. Su, A. Conjusteau, F. Anis, V. Nadvoretskiy, M.A. Anastasio, A.A. Oraevsky: Three-dimensional optoacoustic and laser-induced ultrasound tomography system for preclinical research in mice. Ultrasonic Imaging 2016; 38(1): 77-95. doi: 10.1177/0161734615591163.
Oraevsky AA. ‘‘Contrast agents for optoacoustic imaging: design and biomedical applications’’, Photoacoustics 2015: 2: 1-2, http://dx.doi.org/10.1016/j.pacs.2015.01.002
A.V. Liopo, S. Wang, P.J. Derry, A.A. Oraevsky, E.R. Zubarev, Seedless synthesis of gold nanorods using dopamine as a reducing agent, RSC Advances 2015; 5: 91587-91593.
A.V. Liopo, R. Su, A.A. Oraevsky: Melanin nanoparticles for optoacoustic imaging, Photoacoustics 2015; 3(1): 35-43.
K. Wang, R. Schoonover, R. Su, A. Oraevsky, and M.A. Anastasio, “Discrete imaging models for three-dimensional optoacoustic tomography using radially symmetric expansion functions, IEEE Trans. Med. Imaging, 2014; 33: 180-193.
E.V. Petrova, Sergey A. Ermilov, A.A. Oraevsky: Red blood cell as a universal optoacoustic sensor for non-invasive temperature monitoring. Appl. Phys. Lett. 2014; 105, 094103.
E. Petrova, S. Ermilov, R. Su, V. Nadvoretskiy, A. Conjusteau, A.A. Oraevsky: Using optoacoustic imaging for measuring the temperature dependence of Grüneisen parameter in optically absorbing solutions, Optics Express 2013; 21(21): 025077-025090.
R. Su, SA Ermilov, A. Liopo, A. Oraevsky: Laser optoacoustic tomography: towards new technology for biomedical diagnostics, Nuclear Inst. and Methods in Physics Research-A. 2013; 720: 58-61. DOI: 10.1016/j.nima.2012.12.035.
D. Tsyboulski, A. Liopo, R. Su, S. Ermiov, S. Bachilo, R.B. Weisman, A. Oraevsky: Enabling in vivo measurements of nanoparticle concentrations with three-dimensional optoacoustic tomography, J. BioPhot. 2014; 7(8): 581-588. DOI 10.1002/jbio201200233.
K. Wang, C. Huang, Yu-J. Kao, C-Y. Chou, A.A. Oraevsky, and M.A. Anastasio: Accelerating image reconstruction in three-dimensional optoacoustic tomography on graphics processing units, Med. Phys. 2013; 40, 023301.
Liopo A., Conjusteau A., Tsyboulski D., Ermolinsky B., Kazansky A., Oraevsky A. Biocompatible gold nanorod conjugates for preclinical biomedical research. J Nanomedic Nanotechnol 2012, S2:001. doi: 10.4172/2157-7439.S2-001
R. Su, SA Ermilov, A Liopo, AA Oraevsky: Three-dimensional optoacoustic imaging as a new noninvasive technique to study long-term biodistribution of optical contrast agents in small animal models, J. Biomed. Opt. 2012; 17(10): 101506.
A.V. Liopo, A. Conjusteau, O.V. Chumakova, S.A. Ermilov, R. Su, A.A. Oraevsky: Highly purified biocompatible gold nanorods for contrasted optoacoustic imaging of small animal models. Nanosci Nanotechnol Lett. 2012; 4(7): 681-686.
A.V. Liopo, A. Conjusteau, M. Konopleva, M. Andreeff, A.A. Oraevsky: Laser nanothermolysis of human leukemia cells using functionalized plasmonic nanoparticles. Nano Biomed Eng. 2012; 4(2): 66-75.
K. Wang, R Su, A.A. Oraevsky, M.A. Anastasio: Investigation of iterative image reconstruction in three-dimensional optoacoustic tomography. Phys Med Biol. 2012; 57(17): 5399-5423.
A.V. Liopo, A. Conjusteau, M. Konopleva, M. Andreeff, A.A. Oraevsky: Laser nanothermolysis of human leukemia cells using functionalized plasmonic nanoparticles, Nano Biomed. Eng. 4(2), 66-75 (2012).
H. Lamela, D. Gallego, R. Gutierrez, A. Oraevsky: Interferometric fiber optic sensors for biomedical applications of optoacoustic imaging, J. Biophotonics 2011; 4(3), 184–192.
K. Wang, S.A. Ermilov, R. Su, H-P. Brecht, M.A. Anastasio, A.A. Oraevsky: An imaging model incorporating ultrasonic transducer properties for three-dimensional optoacoustic tomography. IEEE Trans Med Imaging 2011; 30(2): 203-214.
P.V. Chitnis, H-P. Brecht, R. Su, A.A. Oraevsky: Feasibility of optoacoustic visualization of high intensity focused ultrasound-induced thermal lesions in live tissue. J. Biomed. Opt. 2010; 15, 021313.
M.A. Yaseen, S.A. Ermilov, H-P.F. Brecht, R. Su, A. Conjusteau, M. Fronheiser, B. Bell, M. Motamedi and A.A. Oraevsky: Optoacoustic imaging of the prostate: development toward image-guided biopsy, J. Biomed Opt. 2010; 15(2): 021310 (1-8).
M.P. Fronheiser, S.A. Ermilov, H-P Brecht, A. Conjusteau, R. Su, K. Mehta, A.A. Oraevsky: Real-time optoacoustic monitoring and three-dimensional mapping of a human arm vasculature; J. Biomed Opt. 2010; 15(2): 021305 (1-7).
W. Lu, Q. Huang, G. Ku, X. Wen, M. Zhou, D. Guzatov, H-P. Brecht, R. Su, A.A. Oraevsky, L.V. Wang, Chun Li, Photoacoustic Imaging of Living Mouse Brain Vasculature Using Hollow Gold Nanospheres. Biomaterials 2010, 31(3): 348-355.
H. Lamela, D. Gallego, A. Oraevsky: Optoacoustic imaging using fiber-optic interferometric sensors, Opt. Lett. 2009; 34(23): 3695-3697.
A. Conjusteau, S.A. Ermilov, R. Su, H-P. Brecht, M.P. Fronheiser, A.A. Oraevsky, Measurement of the spectral directivity of optoacoustic and ultrasonic transducers with a laser ultrasonic source. Rev. Sci. Inst. 2009; 80: 093708 (1-5).
H.-P. Brecht, R. Su, M. Fronheiser, S. A. Ermilov, A. Conjusteau, and A. A. Oraevsky: Whole body three-dimensional optoacoustic tomography system for small animals, J. Biomed. Optics 2009; 14(6): 0129061-8.
M. Eghtedari, A. Liopo, J.A. Copland, A.A. Oraevsky, M. Motamedi: “Engineering of hetero-functional gold nanorods for the in vivo molecular targeting of breast cancer cells, NanoLetters 2009; 9(1): 287-291.
S. Egerev, S. Ermilov, O. Ovchinnikov, A. Fokin, D. Guzatov, V. Klimov, A. Kanavin, and A. Oraevsky, "Acoustic signals generated by laser-irradiated metal nanoparticles. Appl. Opt. 2009; 48(7), C38-C45.
S. Egerev and A. Oraevsky: Optothermoacoustic phenomena in highly diluted suspensions of gold nanoparticles, Int. J. Thermophys. 2008; 29(2): 2116-2125.
S.A. Ermilov, T. Khamapirad, A. Conjusteau, R. Lacewell, K. Mehta, T. Miller, M.H. Leonard, A.A. Oraevsky: Laser Optoacoustic Imaging System for Detection of Breast Cancer, J Biomed Opt. 2009; 14(2): 024007 (1-14).
D.O. Lapotko, E.Y. Lukianova-Hleb, A.A. Oraevsky: Clusterization of nanoparticles during their interaction with living cells. Nanomed. 2007, 2(2): 241-253.
M. Eghtedari, J.A. Copland, N.A. Kotov, A. Conjusteau, M. Motamedi, A.A. Oraevsky: High Sensitivity of In Vivo Detection of Gold Nanorods Using a Laser Optoacoustic Imaging System, NanoLetters 2007; 7: 1914-1918.
Egerev, S.V., Oraevsky, A.A. Nonlinear optothermoacoustic phenomena in highly diluted suspensions of gold nanoparticles, J. de Physique IV 2006; 137: 273-281.
A.A. Bednov, A.A. Oraevsky: Comparison of glucose effect in model media and biological tissue measured using time-resolved optoacoustic method, Asian J. Phys 2006; 15(1), 55-66.
A.A. Bednov, A.A. Oraevsky: Comparison of glucose effect in model media and biological tissue measured using time-resolved optoacoustic method, Asian J. Phys 2006; 15(1), 55-66.
D.O. Lapotko, E. Lukianova, AA. Oraevsky: Selective laser nano-thermolysis of human leukemia cells with microbubbles generated around clusters of gold nanoparticles, Laser Surg. Med. 2006; 38(6): 631-642.
D. Lapotko, E. Lukianova, M. Potapnev, O. Aleinikova, and A.A. Oraevsky: Laser Activated Nanothermolysis for Elimination of Tumor Cells, Cancer Lett. 2006; 239(5): 36-45.
G.M. Spirou, A.A. Oraevsky, I.A. Vitkin, W.M. Whelan: Optical and acoustic properties at 1064 nm of Polyvinyl-chloride-plastisol for use as a tissue phantom in biomedical optoacoustics, Phys. Med. Biol. 2005; 50: 141-153.
J.A. Copland, M. Eghtedari, V.L. Popov, N. Kotov, N. Mamedova, M. Motamedi, A.A. Oraevsky: Bioconjugated gold nanoparticles as a molecular based contrast agent: Implications for imaging of deep tumors using optoacoustic tomography, Molecular Imaging and Biology 2004; 6(5): 341-349.
S. Emelianov, S. Aglyamov, J. Shah, S. Sethuraman, G. Scott, R. Schmitt, A. Karpiouk, M. Motamedi and A.A. Oraevsky: Synergy of ultrasound, elasticity, and optoacoustic imaging for improved detection and differentiation of cancerous tissue, J. Acoust. Soc. Am. 2004; 115: 2411-2412. doi.org/10.1121/1.4809351
V.G. Andreev, A.A. Karabutov, A.A. Oraevsky: Detection of ultrawide-band ultrasound pulses in optoacoustic tomography, IEEE Trans. UFFC 2003; 50(10): 1383-1391.
D.V. Guzatov, A.A. Oraevsky, A.N. Oraevsky: Plasmon Resonance in ellipsoidal nanoparticles with shells, Quantum Electronics 2003; 33(9): 817-822.
A.A. Karabutov, E.V. Savateeva, A.A. Oraevsky: Optoacoustic Tomography: New Modality of laser diagnostic systems, Laser Physics 2003; 13(5): 711-723.
A.A. Oraevsky, A.A. Karabutov, Time-resolved optoacoustic method and system for noninvasive monitoring of glucose, The Journal of the Acoustical Society of America 2002; 112(6): 2524.
P.S. Grashin, A.A. Karabutov, A.A. Oraevsky, I.M. Pelivanov, N.B. Podymova, E.V. Savateeva, V.S. Solomatin: Distribution of the laser radiation intensity in turbid media: Monte Carlo Simulations, theoretical analysis and results of optoacoustic measurements, Quant. Electron. 2002; 32(10): 868-874.
A.A. Oraevsky, A.N. Oraevsky: Plasmon resonance in ellipsoid nanoparticles, Quant. Electron. 2002; 32(1): 79-82.
A. Oraevsky E. Savateeva, A. Karabutov, B. Bell, R. Johnigan, J. Pasricha, M. Motamedi: Application of confocal optoacoustic tomography in detection of squamous epithelial carcinoma at early stages, In: InVivo Optical Imaging, Workshop at National Institutes of Health, 15 September 1999, ed. by A. Gandjbakhche, Optical Society of America Press, pp. 153-160 (2000).
A.A. Karabutov, E.V. Savateeva, N.B. Podymova, A.A. Oraevsky: “Backward detection of laser-induced wide-band ultrasonic transients with optoacoustic transducer”, J. Appl. Phys. 2000, 87(4): 2003-2014.
A.A. Oraevsky, “Optoacoustic tomography of deeply embedded tumors and early subsurface lesions”, In: Advances in Optical Imaging, Photon Migration and Tissue Optics, Ed. By R. Birngruber, P. French, K. Svanberg, OSA Press, 1999; pp.236-238.
R.O. Esenaliev, A.A. Karabutov, A.A. Oraevsky: Sensitivity of laser optoacoustic imaging in detection of small deeply embedded tumors, IEEE J. ST Quant. Electr. 1999; 5(4):981-988.
A.A. Oraevsky, S.L. Jacques, F.K. Tittel: Measurement of tissue optical properties by time-resolved detection of laser-induced transient stress, Applied Optics, 1997; 36(1): 402-415.
A.A. Oraevsky: Laser optoacoustic imaging for cancer diagnosis, LEOS NewsLetter 1996; 10(6): 17-20.
R.O. Esenaliev, A.A. Oraevsky, S. Rastegar, C. Frederickson, M. Motamedi: Mechanisms of pulsed laser ablation of enamel: The Influence of dye-enhancement and pulse structure. IEEE J.S.T.Quant. Electron. 1996; 2(4): 836-846.
A.A. Oraevsky, L.B. DaSilva, M.D. Feit, M.E. Glinsky, M.D. Perry, A.M. Rubenchik, B.C. Stuart: Plasma mediated ablation of biological tissues with ultrashort laser pulses, IEEE J. S.T. Quant. Electron. 1996; 2(4): 801-809.
A.A. Oraevsky, R.O. Esenaliev, S.L. Jacques, F.K. Tittel, D. Medina: “Breast Cancer Diagnostics by Laser Optoacoustic Tomography”, In: “Trends in Optics and Photonics”, vol. II, ed. by R.R. Alfano and J.G. Fujimoto, OSA Publishing House, pp. 316-321 (1996).
A.A. Oraevsky, S.L. Jacques, F.K. Tittel: Mechanism of laser ablation for aqueous media irradiated under confined-stress conditions. J. Applied Phys. 1995; 78(2): 1281-1290.
A.A. Oraevsky, S.L. Jacques, R.O. Esenaliev, F.K. Tittel: Pulsed Laser Ablation of Soft Tissues, Gels and Aqueous Solutions at Temperatures Below 100 oC. Lasers Surg. Med. 1995; 18(3): 231-240.
A.A. Oraevsky, S.L. Jacques, R.O. Esenaliev, F.K. Tittel: Time-Resolved Optoacoustic Imaging in Layered Biological Tissues", in: "Advances in Optical Imaging and Photon Migration", ed. by Robert R. Alfano, Academic Press, New York, vol. 21, pp. 161-165 (1994).
A.A. Oraevsky, S.L. Jacques, R.O. Esenaliev, F.K. Tittel: Time-Resolved Optoacoustic Imaging in Layered Biological Tissues", in: "Advances in Optical Imaging and Photon Migration", ed. by Robert R. Alfano, Academic Press, New York, vol. 21, pp. 161-165 (1994).
A.A. Oraevsky: A nanosecond acoustic transducer with applications in laser medicine, LEOS Newsletter 1993; 8(1): 6-8.
A.A. Oraevsky, R.O. Esenaliev, V.S. Letokhov, A.A. Karabutov, T.V. Malinsky: Studies of acoustical and shock waves in the pulsed laser ablation of biological tissue. Lasers Surg. Med. 1993; 13(4):470-484.
A.A. Oraevsky, G.H. Pettit, S.L. Jacques, F.K.Tittel, R.A. Sauerbrey, J.H. Nguy, P.D. Henry: XeCl laser induced Fluorescence of atherosclerotic arteries: spectroscopic similarities between lipid-rich lesions and peroxidized lipoproteins, Circulation Res. 1993; 72(1): 84-90.
A.A. Oraevsky, S.L. Jacques, G.H. Pettit, F.K.Tittel, P.D. Henry: XeCl laser ablation of aorta tissue: Luminescence spectroscopy of ablation products. Lasers Surg. Med. 1993; 13(2): 161-178.
A.A. Oraevsky, S.L. Jacques, G.H. Pettit, I.Saidi, F.K.Tittel, P.D. Henry: XeCl laser ablation of aorta tissue: optical properties and energy pathways, Lasers Surg. Med. 1992; 12(6): 585-597.
P.M. Balaban, R.O. Esenaliev, T. Karu, E. Kutomkina, V.S. Letokhov, A.A. Oraevsky: He-Ne laser irradiation of single identified neurons, Laser Surg.Med. 1992; 12(3): 329-337.
A.A. Oraevsky, R.O. Esenaliev, V.S. Letokhov: Temporal characteristics and mechanism of atherosclerotic tissue ablation by picosecond and nanosecond laser pulses. Lasers Life Sci. 5(1-2), 75-93, 1992
A.A. Oraevsky, R.O. Esenaliev, V.S. Letokhov: Pulsed laser ablation of biological tissue: Review of the mechanisms In: Lecture Notes in Physics-Laser Ablation: mechanisms and applications, ed by J.C. Miller and R.F. Haglund, Jr Springer-Verlag, Berlin-Heidelberg-New York-Tokyo, pp. 112-122, 1991
R.O. Esenaliev, A.A. Oraevsky, V.S. Letokhov, E.I. Rabkin, Z.G. Natzvlishvili, Z.A. Kavteladze, A.M. Babunashvili: Investigation into laser ablation of atherosclerotic aorta under CW and pulsed irradiation, Trans.Acad.Sci.USSR (Izvestiya, Phys.) 1990; 549(8), 1586-1599.
A.A. Oraevsky, V.G. Omel'yanenko , S.E. Ragimov, V.S. Letokhov: Differentiation of fibrous plaque and normal zone in atherosclerotic vessels: fluorescence and reflectance spectra. Trans.Acad.Sci.USSR (Izvestiya, ser. phys.) 1990; 549(7), 1398-1405.
E.V. Khoroshilova, O.A. Golavleva, A.A. Oraevsky, D.N. Nikogosyan: Photochemistry of Uridine under high-intensity laser UV excitation. Sov.J.Chem.Phys. 1990; 9(4), 465-476.
R.O. Esenaliev, V. S. Letokhov, A. A. Oraevsky: Laser ablation of atherosclerotic blood vessel tissue under various irradiation conditions. IEEE Trans. BME 1989; 36(12):1188-1199.
Yu.A. Smirnov, S.P. Kapituletz, Y.Y. Zilinsky, R.O. Esenaliev, P.G. Morev, Nikogosyan, A.A. Oraevsky: Inactivation of YEE alpha-virus under high-intensity laser UV irradiation. Sov.J.Biophysics 1989; 34(4), 570-573.
E.N. Dobrov, Z. Kh. Arbieva, E. K. Timofeeva, R. A. Esenaliev, A. A. Oraevsky, D. N. Nikogosyan: UV laser induced RNA - protein crosslinks and RNA chain breaks in tobacco mosaic virus RNA in situ. Photochem Photobiol 1989; 49(5): 595-598.
R.O. Esenaliev, A.A. Oraevsky, D.N. Nikogosyan: Two-quantum cooperative excitation of thymidine in aqueous solution under nanosecond UV laser irradiation. Sov.J.Chem.Phys. 1988; 7(12): 1652-1655.
P.G. Morev, A.A. Oraevsky, D.N. Nikogosyan: Photophysics of electronic excited states of nucleic acids molecules. Sov.J.Chem.Phys. 1988; 7(4), 485-491.
A.A. Oraevsky, V.S. Letokhov, S. E. Ragimov, A. A. Belyaev, B.V. Shekhonin, R. S. Akchurin: Spectral properties of human atherosclerotic blood vessel walls. Lasers in Life Sciences 1988; 2(2):275-288.
A.A. Oraevsky, Letokhov V.S., Omel'yanenko V.G., Ragimov S.E., Belyaev A.A., R.S. Akchurin: Laser spectral analysis of human atherosclerotic vessels. In : Laser Spectroscopy VIII, ed. by S. Svanberg, Springer Series in Optical Sciences, Springer-Verlag, Berlin-Heidelberg-New York, 1987; pp. 370-373.
A.A. Oraevsky, Letokhov V.S., Omel'yanenko V.G., Ragimov S.E., Belyaev A.A., R.S. Akchurin: Laser spectral analysis of human atherosclerotic vessels. In : Laser Spectroscopy VIII, ed. by S. Svanberg, Springer Series in Optical Sciences, Springer-Verlag, Berlin-Heidelberg-New York, 1987; pp. 370-373.
R.O. Esenaliev, A.A. Oraevsky, I.G. Panyutin, D.N. Nikogosyan, G.B. Zavilgelskij: Quantum yields of two- and single- quantum photoreactions in DNA and dinucleotide dTpdT solution under picosecond laser UV excitation. Proc.Natl.Acad.Sci.USSR (biophysics) 1987; 293(1), 232-235.
R.O. Esenaliev, A.A. Oraevsky, I.G. Panyutin, D.N. Nikogosyan, G.B. Zavilgelskij: Quantum yields of two- and single- quantum photoreactions in DNA and dinucleotide dTpdT solution under picosecond laser UV excitation. Proc.Natl.Acad.Sci.USSR (biophysics) 1987; 293(1), 232-235.
A.A. Oraevsky, D.N. Nikogosyan, V.S. Letokhov: Two-quantum UV photolysis of nucleic acid components in aqueous solution in comparison with  - radiolysis. Lasers in Life Sciences 1986; 1(1):49-60.
D.N. Nikogosyan, A.A. Oraevsky, G.B. Zavilgelsky: Picosecond laser inactivation of lambda - bacteriophage and various Escherichia coli strains. Photobiochem Photobiophys 1986; 10(2):189-198.
A.A. Oraevsky: Primary photoprocesses under two quantum UV laser excitation of biomolecules in aqueous solution. Ph.D. Thesis (3 referees), Institute of Spectroscopy, USSR Academy of Sciences, Moscow, 192 p. 1986
D.N. Nikogosyan, A.A. Oraevsky, V. S. Letokhov: Sensitized photodecomposition of the solvent under two-step laser excitation of dissolved molecules. Proc.Natl.Acad.Sci.USSR (Biophysics) 1985; 283(6), 1425-1427.
A.A. Oraevsky, D.N. Nikogosyan: Picosecond two-quantum UV photochemistry of thymine in aqueous solution. Chem Phys 1985; 100(3):429-445.
D.N. Nikogosyan, A.A. Oraevsky, V.S. Letokhov, Z.K. Arbieva, E.N. Dobrov: Two-step UV picosecond excitation of polynucleotides and energy transfer. Chem Phys 1985; 97(1):31-41.
A.V. Kruminsh, A.A. Oraevsky, D.N. Nikogosyan: Tuning of Nd:YAG radiation frequency in visible and infrared region by stimulated Raman scattering in organic liquids. Sov. J Quant. Electron. 1984; 14(7), 1001-1002.
A.A. Oraevsky: Picosecond spectroscopy of primary photoprocesses under two-quantum laser UV photolysis of liquid water. J Molec Struct. 1984; 115(3):461-464.
A.Z. Grasyuk, L.L. Losev, D.N. Nikogosyan, A.A. Oraevsky: High-power picosecond pulse generation in infrared by the stimulated Raman scattering: pulse energy 0.6 mJ in the spectral range of 9.2 µm. Sov.J.Quant.Electr. 1984; 14(9), 1257-1258.
A.A. Oraevsky, D.N. Nikogosyan: Mechanisms of two-photon UV photolysis of pyrimidines in aqueous solution. Sov.J.Chem.Phys. , 1983; 2(9), 1208-1214.
A.A. Oraevsky, D.N. Nikogosyan: Two-photon ionization of liquid water and subsequent transformations of the hydrated electron. Sov.J.Chem.Phys. 1983; 2(7), 943-947.
A.A. Oraevsky, D.N. Nikogosyan, V.I. Rupasov: Primary photochemical processes under two-photon laser UV decomposition of liquid water. Sov.J.Chem.Phys. 1983; 2(3), 394-400.
D.N. Nikogosyan, A. A. Oraevsky, V.I. Rupasov: Two-photon ionization and dissociation of liquid water by powerful laser UV radiation. Chem Phys 1983; 77(1): 131-143.
E.I. Budowsky, A. A. Oraevsky, D.N. Nikogosyan, N.A. Simukova, D. Yu Yakovlev: Direct and indirect action on thymine in aqueous solution by powerful laser UV radiation. Photobiochem Photobiophys 1982; 4(4): 233-239.
D.N. Nikogosyan, D. A. Angelov, A. A. Oraevsky: Determination of parameters of excited states of DNA and RNA bases by laser UV photolysis. Photochem Photobiol 1982; 35(5): 627-635.
A.A. Oraevsky, A. V. Sharkov, D. N. Nikogosyan: Picosecond study of electronically excited singlet states of nucleic acid components. Chem Phys Lett 1981; 83(2): 276-280.
D.A. Angelov, P. G. Kryukov, V. S. Letokhov, D.N. Nikogosyan, A. A. Oraevsky: Efficiency of two-quantum photodecomposition of DNA bases by high-power laser UV irradiation. Sov.J.Quant.Electr. 1981; 8(3), 595-599.
A.A. Oraevsky, D.A. Angelov, D.N. Nikogosyan: Two-photon photolysis of liquid water and its role in two-step photodecomposition of DNA components in aqueous solution. Sov. J. Quant. Electron. 1980; 7(12), 2573-2577.
D.A. Angelov, G.G. Gurzadyan, P. G. Kryukov, V. S. Letokhov, D.N. Nikogosyan, A. A. Oraevsky: High power UV ultrashort laser decomposition of DNA and its components, In : Picosecond Phenomena, ed. by R.M. Hochstrasser, W.Kaiser, C.V. Shank; Springer Series in Chemical Physics. Springer-Verlag, Berlin-Heidelberg-New York, vol.14, pp. 336-339, 1980.
D.A. Angelov, P. G. Kryukov, V. S. Letokhov, D.N. Nikogosyan, A. A. Oraevsky: Selective action on macromolecular chromophores by UV laser pulses. Sov. J. Quant. Electr. 1980; 7(6), 1304-1318.
D.A. Angelov, P. G. Kryukov, V. S. Letokhov, D.N. Nikogosyan, A. A. Oraevsky: Selective action on nucleic acids components by picosecond light pulses. Appl. Phys. 1980; 21(4): 391-395.

AA. Oraevsky, S.L. Jacques, R.O. Esenaliev: "Laser Optoacoustic Imaging System for Medical Diagnostics", USPTO Serial # 05,840,023
R.O. Esenaliev, A.A. Karabutov, M. Motamedi, A.A. Oraevsky: “Real Time Optoacoustic Monitoring of Changes in Tissue Properties”, USPTO Serial # 06,309,352
A.A. Oraevsky, A.A. Karabutov: “Time-resolved optoacoustic method and system for noninvasive monitoring of glucose”, USPTO Serial # 06,405,069.
R. Esenaliev, D. Prough, M. Motamedi, A.A. Oraevsky: “Optoacoustic Monitoring of Blood Oxygenation”, USPTO Serial # 06,498,942.
A.A. Oraevsky, P.M. Henrichs: “High contrast optoacoustic imaging using nanoparticles”, US Patent # 07,500,953, PCT Application # 10/764,213, 01/25/2003
A.A. Oraevsky, D.O. Lapotko: “Laser-activated Nanothermolysis of cells”, US Patent 07,999,161; PCT Application 11/795,857, Priority date 01/22/2005.
A.A. Oraevsky, D.O. Lapotko: “Method of Laser-activated Nanothermolysis of Targeted Cells”, US Patent Application 13/136,939.
A.A. Oraevsky, S.A. Ermilov: “Quantitative Optoacoustic Tomography with Enhanced Contrast”, US Patent 07,740,585, Priority date 01/20/200
A.A. Oraevsky, A. Liopo, “Methods and compositions for carrier agents and clearing agents used in optoacoustic imaging systems”, USPTO Serial No. 13/517,649, Priority Date: Sep 1, 2012, US Patent 9,615,750.
A.A. Oraevsky, S.A. Ermilov, A. Conjusteau, P. Brecht, V.V. Nadvoretrskiy, R. Su, D. Herzog, B. Clingman, J. Zalev: "Dual Modality Imaging System for Coregistered Functional and Anatomical Mapping", U.S. Patent Application Serial No. 13/667,808
A.A. Oraevsky, S.A. Ermilov, A. Conjusteau, P. Brecht, V.V. Nadvoretrskiy, R. Su, D. Herzog, B. Clingman, J. Zalev: Method for Dual Modality Optoacoustic Imaging", U.S. Patent US 9,757,092 B2
A.A. Oraevsky, S.A. Ermilov, A. Conjusteau, P. Brecht, V.V. Nadvoretrskiy, R. Su, D. Herzog, B. Clingman, J. Zalev “Optoacoustic Imaging System Having Handheld Probe Utilizing Optically Reflective Material”, U.S. Patent Application No. US20140039293A1, PCT 13/746,559
A.A. Oraevsky, D. Tsyboulski and T.G. Miller: “Composition of tissue-equivalent opto-acoustic ultrasonic phantoms and assembly method”, U.S. Patent 9,655,594.
A.A. Oraevsky, D.A. Tsyboulski, A. Conjusteau: “Scanning optoacoustic system imaging system with improved signal collection efficiency”, U.S. Patent Application, US Serial 13/748,315, Priority 24 January 2013; Publication US20130190594A1.
A.A. Oraevsky, S.A. Ermilov, A. Conjusteau, Laser Optoacoustic Ultrasonic Imaging System (LOUIS) and Methods of Use; U.S. Patent Application Serial No. 13/748,498, Priority Jan 23, 2012, International App. No. PCT/US2013/022801, US20130190595A1; Canadian CA2861979A1, EP2806803A1, EP2806803A4, EU Patent App. 13740611.2, Japanese Tokugan 2014-553542, International Patent: WO2013112626A1.
A.A. Oraevsky, S.A. Ermilov: Dynamic Optoacoustic Angiography of Peripheral Vasculature; U.S. Patent Application Serial No.: 13/748,563, Priority Jan 23, 2013; CIP Patent U.S. Serial No. 17/074,371.
A.A. Oraevsky, S.A. Ermilov: Optoacoustic-Ultrasonic System for Coregistered Functional and Morphological Imaging of Placentas; US 9,498,133 B2, Date of Patent Nov 22, 2016.
A.A. Oraevsky, A. Liopo, S.A. Ermilov: Optoacoustic-Ultrasonic Contrast Agents with Enhanced Efficiency; U.S. 9,545,456 B2. Date of Patent Jan 17, 2017
A.A. Oraevsky, E. Petrova, S.A. Ermilov: Optoacoustic Image Mapping of Tissue Temperature; U.S. Patent 10,123,707, priority January 31, 2014. International patents: US20150216420 A1, CA2938259A1, EP3099242A1, WO2015117070A1.
A.A. Oraevsky: Screening System for Functional Anatomical Mapping, International PCT patent application PCT/US2019/025885. Priority date: April 4, 2018.
A.A. Oraevsky: Quantitative Imaging System and Uses Thereof; PCT/US2019/025885, U.S. Serial No. 17/063,565. Filed nationally in US, Canada, Australia, Europe, Japan, China, Korea and Russia. Priority Date of Application April 4, 2019.